Manual hubs are great, and they are the only way to absolutely lock the front wheels in. They either lock when you turn the handle, right then, or as soon as the axle turns at a slightly different speed than the wheel. Such as when stuck or turning.
They work by a spring pushing on a sliding collar that engages two splines. This allows you to always be able to turn the knob, and for them to pop in as soon as they line up.
when stuck, you will never have a time when you are spinning the rears and the front are waiting to engage. The fronts will engage instantly, when the axle turns at a different speed than the wheel, or when you actually turn the knob.
If you are going up to the mountains, or out into some mud, engage the hubs before you get there. This lubes up the gears and everything will be ready when you need it. While on the highway, you can engage 4 high while rolling if you get into some snow.
I'd consider the vacuum hub system to be a convenience that lets you stay in the truck if you happen to get stuck unexpectedly, but not as a normal way of running the front axle, or as a way to drive for miles in the snow.
In an F150 , a Wrangler, a Ram, or a Chevy, where you don't have manual hubs, the engagement is a different process. If there is a center axle disconnect, a CAD, that has to engage as well as the transfer case. And it has to happen smoothly, so there is a delay, or you have to stop. Without a CAD, 4 high can simply be engaged on the fly with no delay, bt the front diff is always turning whether you need it or not.
Some old International pickups had "automatic" hubs. These worked by having an overunning clutch in each hub that sensed if the axle was turning faster than the wheel. Then it would engage. But it would disengage if no power was being applied, so it was not reliable for holding back. It was only good for getting unstuck. If using 4WD for longer periods or while out exploring, the y had to be manually engaged wit the knob
For heavy duty trucks, like the Super Duty, manual hubs are the best of all, and very "old school". Vacuum hubs are just a modern way to make them more convenient. but it can never be as reliable. One of the reasons I bought a Tremor was that it has manual hubs. Ram doesn't.
If you think you are going to need 4WD, engage the hubs manually before you get there.